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ISES Europe Exposure Model Inventory

This model and tool inventory was assembled and is curated by the Working Group Exposure Models of the European chapter of the International Society on Exposure Science (ISES Europe).

Version number / Date:  1.0 / March 2022

This inventory cannot be complete but aims to include the most important exposure models and tools used in the EU now. The ISES Europe model inventory is intended as a living document that is accessible via the ISES Europe platform on the ISES Europe Website.

This table consists of four sheets (and this "Read me" sheet):

- Worker with tools and models for exposure assessment of occupational exposure due to handling of chemicals at workplaces

- General population (human) with tools and models for exposure assessment of humans via the environment and for exposure assessment due to handling of chemicals by consumers (including different sub-populations)

- Environmental Exp. (ecosystem) with tools and models for exposure assessment of environmental compartments due to emissions to the environment

- Dosimetry & PBPK with tools and models for “internal exposure assessment”

Models and tools that were specifically designed for the exposure assessment of nano materials are placed in one of the above-mentioned sheets. Most of those tools are developed for occupational exposure assessment and are placed in the worker sheet.

If a model or tool cannot be assigned clearly to one sheet only, it will be explained in detail in one of the sheets. In the other sheets there will be a reference to that sheet.

Models or tools that cannot be found in the internet (homepage of the model or tool or a scientific publication as a minimum) will not be included in this inventory.

If you, as a user of this inventory, find a mistake or want to add an important model, please get in contact with

Documentation of the virtual Workshop on "Theoretical Background of Occupational Exposure Models"

ISES Europe identified exposure modelling as one of the major issues for the strategic development of exposure science in Europe for the next years. The aim of this workshop was to discuss the main challenges in developing, validating and using occupational exposure assessment models for regulatory purposes. Exposure modelling approaches were introduced and the theoretical background, application and limitations have been presented and discussed.

Workshop participants discussed the applicability of the currently available models with the aim to reach a common understanding of the benefits and limitations of the different ways of exposure modelling and to draw a roadmap towards future exposure modelling initiatives. Some more information about the issues for discussion are presented in the background document (Background Document).

The presentations are available here:

  1. Opening, logistics, agenda, aim of the workshop, Natalie von Goetz (BAG)
  2. Concept of STOFFENMANAGER® and ART Source receptor modelling approach, John Cherrie (HWU)
  3. Mass balance modelling approach, Susan Arnold (UMN)
  4. Requirements for the validation of models, Dorothea Koppisch (IFA)
  5. Requirements for regulatory exposure modelling, Celia Tanarro (ECHA)

Additionally, a narrative documentation of the main discussion topics and outcomes will be made available here at a later stage.

European exposure science strategy building paper

Exposure information is a critical element in various regulatory and non-regulatory frameworks in Europe and elsewhere. Exposure science supports to ensure safe environments, reduce human health risks, and foster a sustainable future. However, increasing diversity in regulations and the lack of a professional identity as exposure scientists currently hamper developing the field and uptake into European policy. In response, we discuss trends, and identify three key needs for advancing and harmonizing exposure science and its application in Europe. We provide overarching building blocks and define six long-term activities to address the identified key needs, and to iteratively improve guidelines, tools, data, and education. More specifically, we propose creating European networks to maximize synergies with adjacent fields and identify funding opportunities, building common exposure assessment approaches across regulations, providing tiered education and training programmes, developing an aligned and integrated exposure assessment framework, offering best practices guidance, and launching an exposure information exchange platform. Dedicated working groups will further specify these activities in a consistent action plan. Together, these elements form the foundation for establishing goals and an action roadmap for successfully developing and implementing a ‘European Exposure Science Strategy’ 2020–2030, which is aligned with advances in science and technology.

Fantke, P., von Goetz, N., Schlüter, U., Bessems, J., Connolly, A., Dudzina, T., Ahrens, A., Bridges, J., Coggins, M.A., Conrad, A., Hänninen, O., Heinemeyer, G., Kephalopoulos, S., McLachlan, M., Meijster, T., Poulsen, V., Rother, D., Vermeire, T., Viegas, S., Vlaanderen, J., Zare Jeddi, M., Bruinen de Bruin, Y., 2019. Building a European exposure science strategy. Journal of Exposure Science and Environmental Epidemiology. doi:10.1038/s41370-019-0193-7


ISES Europe 2018 workshop report

Bruinen de Bruin, Y., von Goetz, N., Schlüter, U., Bessems, J., Connolly, A., Dudzina, T., Ahrens, A., Bridges, J., Coggins, M., Conrad, A., Crépet, A., Heinemeyer, G., Hänninen, O., Kephalopoulos, S., McLachlan, M., Meijster, T., Poulsen, V., Rother, D., Vermeire, T., Viegas, S., Vlaanderen, J., Zare Jeddi, M., Fantke, P., 2019. Assessment of Needs for a European Strategy on Exposure Science. ISES Europe, ISBN: 978-87-971147-0-4